SYNGAP1 Controls the Maturation of Dendrites, Synaptic Function, and Network Activity in Developing Human Neurons

SYNGAP1 Controls the Maturation of Dendrites, Synaptic Function, and Network Activity in Developing Human Neurons

SYNGAP1 is a serious genetic danger issue for international developmental delay, autism spectrum dysfunction, and epileptic encephalopathy. De novo loss-of-function variants on this gene trigger a neurodevelopmental dysfunction outlined by cognitive impairment, social-communication dysfunction, and early-onset seizures. Cell organic research in mouse and rat neurons have proven that Syngap1 regulates growing excitatory synapse construction and performance, with loss-of-function variants driving formation of bigger...