Unveiling Sex-Based Differences in the Effects of Alcohol Abuse: A Comprehensive Functional Meta-Analysis of Transcriptomic Studies

Unveiling Sex-Based Differences in the Effects of Alcohol Abuse: A Comprehensive Functional Meta-Analysis of Transcriptomic Studies

The abuse of alcohol, one of the well-liked psychoactive substances, may cause a number of pathological and psychological penalties, together with alcohol use dysfunction (AUD). An impaired capability to cease or management alcohol consumption regardless of opposed well being or social penalties characterize AUD. Whereas AUDs predominantly happen in males, rising proof suggests the...

SYNGAP1 Controls the Maturation of Dendrites, Synaptic Function, and Network Activity in Developing Human Neurons

SYNGAP1 Controls the Maturation of Dendrites, Synaptic Function, and Network Activity in Developing Human Neurons

SYNGAP1 is a serious genetic danger issue for international developmental delay, autism spectrum dysfunction, and epileptic encephalopathy. De novo loss-of-function variants on this gene trigger a neurodevelopmental dysfunction outlined by cognitive impairment, social-communication dysfunction, and early-onset seizures. Cell organic research in mouse and rat neurons have proven that Syngap1 regulates growing excitatory synapse construction and performance, with loss-of-function variants driving formation of bigger...

Genes associated with cognitive performance in the Morris water maze: an RNA-seq study

Genes associated with cognitive performance in the Morris water maze: an RNA-seq study

Studying and reminiscence are amongst higher-order cognitive capabilities which might be primarily based on quite a few molecular processes together with modifications within the expression of genes. To determine genes related to studying and reminiscence formation, right here, we used the RNA-seq (high-throughput mRNA sequencing) know-how to check hippocampal transcriptomes between mice with excessive and low Morris water...